Adverse effects include dryness of the skin, lips, nasal passages and eyes.

Adverse pregnancy outcome including spontaneous abortions and major birth defects.

Use in women of child-bearing age requires at least one month of effective contraception before initiating therapy, during therapy and for one month after discontinuing the drug.

Two negative pregnancy tests are strongly recommended before initiating therapy and should be confirmed monthly while on treatment.

Depression, psychosis and suicide linked to use.

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