Zuranolone is a medication used for the treatment of postpartum depression.

Trade names Zurzuvae

Pregnancy category-Contraindicated

Routes of administration-oral 

An orally active inhibitory pregnane neurosteroid, zuranolone acts as a positive allosteric modulator of the GABAA receptor.

Drug class Neurosteroid; GABAA receptor positive allosteric modulator

Protein binding 99.5%

Metabolism CYP3A4

Elimination half-life 16–23 hours

It is taken by mouth.

The most common side effects include drowsiness, dizziness, diarrhea, fatigue, nasopharyngitis, and urinary tract infection.

It can impact a person’s ability to drive and perform other potentially hazardous activities.

Use of zuranolone may cause suicidal thoughts and behavior.

Zuranolone may cause fetal harm.

Participants with postpartum depression in the zuranolone group showed significantly more improvement in their symptoms compared to those in the placebo group.