Zinc finger transcription factors or ZF-TFs, are transcription factors composed of a zinc finger-binding domain and any of a variety of transcription-factor effector-domains that exert their modulatory effect in the vicinity of any sequence to which the protein domain binds.
Zinc finger protein transcription factors allow for the medical intervention and control of expression of multiple genes and the initiation of an elaborate cascade of events.
Ikaros and Aiolos encode hemopoietic-specific zinc finger transcription factors that are important regulators of lymphocyte differentiation.