Majority of cases are squamous cell type.
A serious gynecological emergency, accounting for about 5% of all female genital cancers.
Vulvar squamous cell carcinoma is the most predominant histological subtype of a vulvar cancer and the accounts for more than 90% of cases.
Lesions include keratinizing and non-keratinizing basaloid, warty, and verrucous carcinoma.
Vulvar cancer can be proceeded by intraepithelial neoplasia.
Women generally over the age of 50 years.
Associated with HPV types 6, 16, 11, 18, 31, 33,45,52, and 58.
Vulvar cancer and vulvar intraepithelial neoplasia have high positivity for HPV DNA and p16 high prevalence.
Biopsy of any atypical lesion should be performed.