Used to lower parathyroid hormone levels and commonly utilized with calcium containing phosphate binders.
Can cause hypercalcemia and hyperphosphatemia by increasing intestinal absorption of calcium and phosphorus.
Can lead to metabolic disturbances that int2242upt treatment, impair biochemical control and permit progression of bone disease.
Can lead to increased arterial stiffness, calcifications of coronary arteries, aorta, heart valves and can increase risk of death.
Approximately 20% of patients have treatment held because of development of hypercalcemia and elevated serum phosphorus.