A serine protease that is the final mediator in the coagulation cascade that leads to the production of fibrin and the formation of blood clots.
Critical for thrombosis.
Activation of thrombin leads to: conversion of fibrinogen to fibrin, activation of platelets, consumption of platelets, activation of factors V and VIII, activation of protein C, degradation of factors Va and VIIIa, activation of endothelial cells, and activation of fibrinolysis.
A potent activator of platelets.
Generates fibrin and is a potent agonist of platelets through interaction with protease-activate receptors.
Activated platelets by cleaving and activating protease activated receptors 1 and 4.
Protease-activated receptor-1 (PAR-1) Is the major thrombin receptor on human platelets.
Cyclic AMP in platelets int2242upts multiple signaling pathways and plays a role in down-regulating platelet activation.
Thrombin inhibiting drugs can block its action by binding to three domains: the active site, the catalytic site, and 2 exosites.