Testosterone has been associated with injury risk for decades based on anecdotes from bodybuilders and professional athletes.
Steroid rage refers to violent aggressive behavior with the use of illicit high-dose testosterone.
Endogenous high testosteronrelevels are associated with risk taking behavior in prison inmates, financial traders, adults who who gamble, and teens of both sexes.
Testosterone treatment is associated with other adverse effects:
Thrombolic risk in some studies, possible increase in myocardial infarction, cerebral vascular stroke, and pulmonary thromboembolism.
Testosterone is associated with worsinging acne in transgender adults receiving testosterone supplementation, gynecomastia, alopecia, hirsutism.
While exogenous testosterone treatment is a proposed management for frailty it does not consistently improve walking speed, cognition or psychological mood.
The net affects of testosterone treatment on physical strength, quality of life, subjective vitality is variable.
About $2 billion is spent annually on testosterone products each year.
One in 25 US men after age 60 are receiving testosterone treatment.
Up to 1/4 of patients prescribed testosterone have not had a testosterone level measured in the year before initiating treatment.
In the study of 60,000 adults prescribed testosterone by a physician, it was found that serious injury leading to emergency care was a common complication, with rates of intentional injury being high (Yarnell CJ).
The relative risk of serious injury was no higher after starting testosterone compared with before starting testosterone.
There was a significant increase in subsequent thromboembolic events including ischemic stroke, myocardial infarction and pulmonary embolism.