SRY-box 17 is a protein that in humans is encoded by the SOX17 gene.
The gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors, located on Chromosome 8 q11.23.
SOX17 is involved in the regulation of vertebrate embryonic development and in the determination of the endodermal cell fate.
The encoded protein acts downstream of TGF beta signaling (Activin) and canonical WNT signaling (Wnt3a).
It is crucial for the activation of cardinal endodermal genes to enter the definitive endodermal lineage.
SOX17 helps mediate immune invasion during the formation of colorectal cancers by influencing the formation of the gut endoderm and the vascular system,and has rolls in endometrial receptivity and embryo implantation.
In adults, SOX17 is usually epigenetically silenced, which enables immune surveillance through up regulation of major histocompatibility complex (MHC) class 1 expression and interferon gamma receptor.
SOX17 is a gene that encodes a member of the SRY-related HMG-box (SOX) family of transcription factors.
These proteins play a crucial role in regulating embryonic development and determining cell fate.
Mutations or dysregulation of SOX17 have been associated with various developmental disorders and diseases, including congenital heart defects and certain types of cancer.