Circulating form of a glycosyl-phosphatidylinositol-anchored three domain membrane protein expressed on a variety of cells, including immunologically active cells, endothelial cells, and podocytes.
The circulating and membrane-bound forms are involved in the regulation of cell adhesion and migration through binding of integrins.
Soluble urokinase plasminogen activator receptor (suPAR) is normally expressed at low levels on endothelial cells, podocytes and with induced expression immunologically active cells such as monocytes and lymphocytes: levels are predictive of progressive decline and kidney function.
suPAR Elevation results in proteinuria.
Soluble urokinase plasminogen activator receptor (suPAR) is a signaling glycoprotein involved in the pathogenesis of kidney disease: high levels are associated with acute kidney injury in various clinical contexts (Hayek SS).