Pramocaine also known as pramoxine is a topical anesthetic and used as an antipruritic.
It is a potent and of low acute and subacute toxicity, well tolerated by most mucous membranes and of a low sensitizing index.
Like other local anesthetics, pramocaine decreases the permeability of neuronal membranes to sodium ions, blocking both initiation and conduction of nerve impulses.
Depolarization and repolarization of excitable neural membranes is inhibited, leading to numbness.
Trade names Analpram HC, Caladryl, Caladryl Clear, Cortane-B, Epifoam, Gold Bond Maximum Relief, Itch-X, Pramosone, Prax, Proctodan-HC, Proctofoam, Tronolane, Vagisil Medicated
Routes of administration-Topical, rectal, Vaginal
Topical anesthetics are used to relieve pain and itching caused by sunburn or other minor burns, insect bites or stings, poison ivy, poison oak, poison sumac, and minor cuts and scratches.
The hydrochloride salt form of pramocaine is water-soluble.
Pramocaine is a common component of over the counter hemorrhoid preparations.
Pramocaine is also included in some topical antibiotics like Neosporin.