Podophyllum resin, podophyllin, is a resin used as a medication to treat genital warts and plantar warts, including in people with HIV/AIDS.
Application by a healthcare provider to the skin is recommended.
Podophyllin, contains the active agent podophyllotoxin, which is a cytotoxic agent that arrests mitosis in metaphase.
It is a physician-applied medicine used in the treatment of external genital warts and condyloma acuminatum.
Podophylli can causes tissue injury but also can be absorbed systemically and cause neurologic toxicity.
Pregnancy category US: X (Contraindicated).
Podophyllotoxin which stops cell division.
Side effects include: skin redness, itchiness, and pain at the site of use, vomiting, abdominal pain, confusion, bone marrow suppression, and diarrhea.
Deaths have occurred with the use of podophyllin on exuberant perianal warts; the surface area of the lesions increases the absorption of the drug.
It is used on a small area at a time, as Increased surface area of the lesions increases the absorption of the drug.