Such agents by him directly to DNA, forming a platinum/DNA adduct that causes intra-or interstrand DNA cross links, resulting in double strand DNA breaks.
Platinum agents bind to and damage DNA, producing partly reactive platinum in the serum and platinum–DNA adducts in human organs, detectable up to 20 years after chemotherapy,and may contribute in part to several toxicities.
Double-strand DNA breaks trigger growth arrest and augment DNA repair mechanisms may also induce cell death.
Whether cells damaged by platinum agents lives or dies partly dependent on the efficiency of repair pathways.
Long-term toxicities following cisplatin-based chemotherapy include cardiovascular disease, pulmonary dysfunction, secondary neoplasms, years after treatment have been discontinued.
Peripheral paresthesias, Raynaud’s phenomenon, hearing impairment, and tinnitus have a prevalence of 30-40% in long-term survivors.
Platinum agents bind to and damage DNA, producing partly reactive platinum in the serum and platinum–DNA adducts in human organs, detectable up to 20 years after chemotherapy,and may contribute in part to several toxicities.