Proinflammatory phospholipid synthesized and secreted by mast cells, macrophages and monocytes.
Activity controlled by platelet activating factor acetylhydrolase, a enzyme that degrades platelet activating factor.
Circulating levels controlled by platelet activating factor acetylhydrolase, to some degree.
After binding to receptors on platelets, monocytes, macrophages and neutrophils, can lead to manifestations of anaphylaxis.
Circulating levels increased in proportion to severity of allergic reactions.
Platelet activating factor acetylhydrolase activity is decreased by severity of organ involvement with acute allergic reactions.