P62 protein also known as sequestosome-1 (SQSTM1), plays a crucial role in cellular processes such as protein degradation and autophagy.
It acts as a selective autophagy receptor and is involved in the clearance of damaged or unwanted cellular components.
One of the main functions of p62 is to recognize and interact with ubiquitinated proteins, which are marked for degradation.
p62 binds to ubiquitin-tagged proteins and targets them for degradation via autophagy.
Autophagy is a process by which cells recycle and degrade their own components, including proteins, to maintain cellular homeostasis.
p62 is involved in signaling pathways that are associated with inflammation, oxidative stress, and cell survival.
It interacts with other proteins and organelles within the cell.
Mutations or dysregulation of p62 have been associated with neurodegenerative disorders such as Parkinson’s disease, Alzheimer’s disease, and amyotrophic lateral sclerosis (ALS).
p62 accumulation is observed in certain types of cancer and possibly contributes to tumor progression and resistance to cancer treatments.
Overall, p62 is a multifunctional protein that plays a crucial role in protein degradation, autophagy, cellular signaling, and disease pathogenesis.