Notch proteins are a family of Type-1 transmembrane proteins.
They form a core component of the Notch signaling pathway.
The Notch extracellular domain (NECD) mediates interactions which allow it to participate in juxtacrine signaling.
Notch family members operate in different tissues and play a role in a variety of developmental processes by controlling cell fate decisions.
Humans have four Notch variants, Notch 1-4.
For all Notch family proteins, the protein can broadly be split into the Notch extracellular domain (NECD) and Notch intracellular domain (NICD) joined together by a single-pass transmembrane domain (TM).
Notch family members play a role in a variety of developmental processes by controlling cell fate decisions, and regulates interactions between physically adjacent cells.
A deficiency can be associated with bicuspid aortic valve.
There is evidence that activated Notch 1 and Notch 3 promote differentiation of progenitor cells into astroglia.
Notch signaling is triggered by direct cell-to-cell contact.
Notch is mediated by interactions between the Notch receptor protein in the signal receiving cell and a ligand in an adjacent signal transmitting cell.