Syndrome consists of the triad of erythema nodosum, bilateral hilar lymphadenopathy on chest radiograph, and arthralgia.
A type of acute sarcoidosis that is frequent in Scandinavian, Irish, African and Puerto Rican women.
It is characterized by hilar lymphadenopathy as seen on x-ray, and erythema nodosum are classically present on the shins, predominantly in women.
It may also be accompanied by arthritis and fever.
The arthritis is often acute and involves the lower extremities, as is more frequent in men.
Lofgren syndrome arthritis occur most frequently in the ankles, followed by the knees, wrists, elbows, and metacarpophalangeal joints.
Lofgren syndrome arthritis occur most frequently in the ankles, followed by the knees, wrists, elbows, and metacarpophalangeal joints.
Lofgren syndrome arthritis is a operiarthritis that appears as a swelling in the soft tissue around the joints.
The combination of hilar lymphadenopathy and ankle periarthritis can be considered as a variant of
Lofgren syndrome.
Patients usually have a very good prognosis, especially those who are HLA-DRB1-03 positive.
Asociated with a good prognosis,with more than 90% of patients experiencing disease resolution within 2 years.
Patients with the disfiguring skin condition lupus pernio or cardiac or neurologic involvement rarely experience disease remission.
Recent studies have demonstrated that the HLA-DQB1*0201 is strongly associated with Lofgren syndrome.
It is associated with HLA-DRB1*03.
NSAIDs are the usual recommended treatment for Lofgren syndrome.