Interleukin-10

Restricts excessive immune responses, and is a soluble factor released by type 2 helper T cells.

An immune regulatory cytokine with anti-inflammatory properties but with stimulatory functions on B cells and CD8 positive and T cells.

Frequently considered an immune-suppressive and tumor promoting cytokine.

Enhances the proliferation and survival of the differentiation, the expression of the major histocompatibility complex class I
I molecules, immunoglobulins and isotype switching in B cells.

Inhibits secretion of type I helper T cytokines interleukin-2 and interferon gamma.

Secreted by a variety of cells and has effects on T cells, B. cells, myeloid cells and other cell types as well.

It limits the secretion of inflammatory cytokines such as TNF-alpha and IL-12.

Mutations in genes encoding the IL-10 receptor found in patients with early onset enterocolitis with a hyper inflammatory immune response in the intestine.

Considered a promoter of lymphoma.

One third of patients with interleukin-10 receptor deficiency develop B-cell lymphomas in the first decade of life.

The IL-10 receptor is expressed only on the hematopoietic cells and in particular on cells of the immune system.

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