Estimated that greater than 2% of all genes are regulated by HIF.
Involved in regulation of oxygen transport capacity of the blood because it stimulates EPO production when oxygen delivery to the kidney and the liver is reduced.
Target gene activation includes promotion of angiogenesis and regulation of vascular tone.
Under hypoxic conditions, hypoxia inducible factor (HIF-1) is thought to induce the synthesis of erythropoietin and vascular endothelial growth factor, as well as other growth factors.
HIF is regulated by oxygen dependent proteasomal degradation with a family of prolyl hydroxylases serving as oxygen sensors.
A link between intermediates of the citric acid cycle and the regulation of hypoxia-inducible factors (HIF) exists.
HIF plays a role in the regulation of oxygen homeostasis, and is a transcription factor that targets angiogenesis, vascular remodeling, glucose utilization, iron transport and apoptosis.
HIF is synthesized constitutively, and hydroxylation of at least one of two critical proline residues mediates their interaction with the von Hippel Lindau E3 ubiquitin ligase complex, which targets them for rapid degradation.
Helps to adapt to hypoxia.
A key mediator in responses of decreased PO2, the hypoxia-inducible factor, a gene transcription factor that regulates cellular responses to hypoxia including cellular metabolism, angiogenesis, and erythropoiesis.
Transcriptional regulation by a link between intermediates of the citric acid cycle and the regulation of hypoxia-inducible factors (HIF).
HIF plays a role in the regulation of oxygen homeostasis, and is a transcription factor that targets angiogenesis, vascular remodeling, glucose utilization, iron transport and apoptosis.
HIF is synthesized constitutively, and hydroxylation of at least one of two critical proline residues mediates their interaction with the von Hippel Lindau ubiquitin ligase complex, which targets them for rapid degradation.
HIF promotes gene expression of VEGF and glycolytic enzymes, allowing metabolism in oxygen-depleted environments.
Adaptation to hypoxia is associated with increased respiration, blood flow and survival responses.
Other adaptation mechanisms rely on oxygen-sensing prolyl hydroxylases, which hydroxylate prolines in the alpha subunit of the hypoxia-inducible transcription factor(HIF).
HIF is a heterodimer transcription factor with 2 subunits: HIF-1alpha or HIF-2alpha and HIF-1Beta.
HIF-1beta is ubiquitous, whereas HIF-2alpha is restricted to certain tissues.
Affects a number of cellular processes including glucose transport, cell metabolism, angiogenesis, cell proliferation, apoptosis, erythropoiesis, vascular tone and extra cellular matrix.
Elevated levels of HIF-1alpha protein correlates with poor prognosis in most solid tumor evaluations (Zhong H).
Elevated levels of HIF-1alpha protein associated with a good prognosis in patients treated for diffuse large B-cell lymphoma treated with R_CHOP, but not with CHOP alone (Evens AM).