Extract contains 22-27% flavonoids and 5-7% terpene lactones.
Terpene lactones are derived from G biloba trees and consist of several ginkolides and bilobalide.
The flavonoids are antioxidants and are neuroprotective.
Ginkolides B is a potent platelet antagonist of the platelet activating factor.
Proposed mechanism is action is as an antioxidant.
In a randomized trial of 3069 older adults with normal cognition or mild impairment there was no benefit in reducing all cause dementia or Alzheimer’s disease (Gingko Evaluation of Memory Study ).
Compared with placebo the use of ginkgo biloba resulted in no improvement in cognitive decline in older adults with normal cognition or with mild cognitive impairment (Gongko Evaluation of Memory Study).