Fluxomics seek to determine the rates of metabolic reactions within a biological entity.
Metabolomics provide instantaneous information on the metabolites in a biological sample: metabolism is a dynamic process.
Fluxomics indicates that metabolic fluxes determine the cellular phenotype, and it is based on the metabolome.
Metabolic flux refers to the rate of metabolite conversion in a metabolic network.
A reaction rate is a function of both enzyme abundance and enzyme activity.
Enzyme concentration is a function of transcriptional and translational regulation in addition to the stability of the protein.
Enzyme activity is affected by the substrate concentrations, the product concentrations, and the effector molecules concentration.
The genomic and environmental effects on metabolic flux determine ahealthy or diseased phenotype.
The fluxome is defined as the complete set of metabolic fluxes in a cell.\
It is a dynamic representation of the phenotype resulting from the interactions of the metabolome, genome, transcriptome, proteome, post-translational modifications and the environment.
The fluoxome can only be measured indirectly, as the critical link between genes, proteins and the observable phenotype.
Fluxomics provide a quantifiable representation of the effect the environment has on the phenotype because the fluxome describes the genome environment interaction.