Receptor pathway that plays and important role in chemotherapy induced apoptosis.
Alteration in expression of Fas and or FasL by malignant cells can impact chemotherapy sensitivity to tumors.
Chemotherapy agents can induce FasL expression on solid tumors and biologic agents can increase Fas and increased the activity of FasL inducing drugs.
Fas expression correlates inversely with the metastatic potential of osteosarcoma.