May be related to the development of cancer and problems with aging.
Multiple exogenous and endogenous factors constantly induce tens of thousands of DNA breaks every day, and DNA complex repair machineries are key checkpoints to guarantee cell integrity, and prevent the initiation of malignant neoplasm.
DNA damage types include single strand of double strand breaks, base damage, bulky addicts, cross-links, or replication lesions.
Genome stability supported by repair mechanisms, damage tolerance and pathways that counteract DNA (Deoxyribonucleic acid) damage.
When present can promote survival responses that are antiaging, anticancer and can suppress metabolism and growth and can strengthen defense mechanisms to maintain integrity of the cell.
Occurs because biologic molecules are subject to chemical reactions.
Enzymatic receptors can produce free radicals that can cause harmful effects on biologic molecules.
Exposure to x-rays, ultraviolet radiation, and a wide variety of chemicals can damage cell structures.