For the treatment of tardive dyskinesia
Approved for the treatment of tardive dyskinesia (TD) in adults.
Trade name Austedo.
For the treatment of chorea associated with Huntington’s disease.
The approval as a TD treatment comes less than 5 months after valbenazine became the first drug approved as a treatment for the movement disorder.
It is a selective vesicular monoamine transporter 2 (VMAT2) inhibitor.
Pregnancy category AU: B3
Routes of administration By mouth
Deutetrabenazine is a vesicular monoamine transporter 2 inhibitor which is used for the treatment of chorea associated with Huntington’s disease and tardive dyskinesia.
Chemically, deutetrabenazine is an isotopic isomer of tetrabenazine in which six hydrogen atoms have been replaced by deuterium atoms.
The incorporation of deuterium slows the rate of drug metabolism, allowing less frequent dosing.
Deutetrabenazine provides a significant reduction in tardive dyskinesia, with favorable safety and tolerability.
Deutetrabenazine acts as a monoamine-depleting agent.
Adverse effects of deutetrabenazine include akathisia, agitation, restlessness, sedation, nasopharyngitis, and insomnia.
Deutetrabenazine is a vesicular monoamine transporter inhibitor which is used for the treatment of chorea associated with Huntington’s disease and tardive dyskinesia.
Deutetrabenazine acts as a monoamine-depleting agent.
Deutetrabenazine is used to treat movement disorders, including tardive dyskinesia and chorea caused by Huntington’s disease.
Deutetrabenazine works in the central nervous system (CNS) to prevent the absorption of certain chemicals (eg, dopamine, serotonin, norepinephrine, histamine).
Using this medicine with any of the following medicines is not recommended.
Bepridil Cisapride Dronedarone Furazolidone Iproniazid Isocarboxazid Levoketoconazole Linezolid Mavorixafor Mesoridazine Methylene Blue Moclobemide Nialamide Phenelzine Pimozide Piperaquine Procarbazine Rasagiline Reserpine Safinamide Saquinavir Selegiline Sparfloxacin Terfenadine Tetrabenazine Thioridazine Tranylcypromine Ziprasidone
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases.
Abiraterone Acetate Abiraterone Acetate, Micronized Adagrasib Alfuzosin Amiodarone Amisulpride Amitriptyline Anagrelide Apomorphine Aripiprazole Arsenic Trioxide Asenapine Astemizole Atazanavir Azithromycin Bedaquiline Buprenorphine Bupropion Buserelin Celecoxib Ceritinib Chloroquine Chlorpromazine Ciprofloxacin Citalopram Clarithromycin Clofazimine Clomipramine Clothiapine Clozapine Crizotinib Cyclobenzaprine Dabrafenib Dasatinib Degarelix Delamanid Desipramine Deslorelin Desvenlafaxine Dexmedetomidine
Swallow the tablet and the extended-release tablet whole with water:Do not crush, break, or chew it.
Used fortardive dyskinesia and chorea caused by Huntington’s disease:
Deutetrabenazine may cause some people to be agitated, irritable, or display other abnormal behaviors.
It may also cause some people to have suicidal thoughts and tendencies or to become more depressed, especially if they have Huntington’s disease.
This medicine may cause parkinsonism.
This medicine may cause drowsiness, trouble with thinking, or trouble with controlling movements.
Dizziness, lightheadedness, or fainting may occur, especially when you get up from a lying or sitting position.
It adds to the effects of alcohol and other central nervous system (CNS) depressants.
Side Effects
More common Body aches or pain Chills Diarrhea Difficulty with breathing Difficulty with swallowing Discouragement Drowsiness Dry mouth Fear Feeling sad or empty Fever Headache Inability to sit still Irritability Lack of appetite Loss of balance control Loss of interest or pleasure Mask-like face Need to keep moving Nervousness Relaxed and calm feeling Restlessness Shuffling walk Sleepiness or unusual drowsiness Slow movement or reflexes Slurred speech Stiffness of the arms and legs Tic-like (jerky) movements of the head, face, mouth, and neck Tiredness Trembling and shaking of the fingers and hands Trouble concentrating Trouble sleeping Trouble with balance Unusual tiredness or weakness Less common Agitation Dizziness Problems passing stools
Symptoms of overdose Blurred vision Confusion Dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position Fixed position of the eye Inability to move the eyes Increased blinking or spasms of the eyelid Mood or mental changes Nausea Seeing, hearing, or feeling things that are not there Shakiness in the legs, arms, hands, or feet Sticking out of the tongue Sweating Trembling or shaking of the hands or feet Uncontrolled twisting movements of the neck, trunk, arms, or legs Unusual facial expressions Vomiting
These side effects may go away during treatment as your body adjusts to the medicine.
More common Bruising Large, flat, blue patches on the skin Less common Muscle aches Sore throat Stuffy or runny nose