A rare invasive, sometimes life-threatening fungal infection caused by dermatophytes.
Filamentous fungi are ubiquitous and usually cause benign infections limited to his skin and lead to onychomycoses, tinea corporis, times cruris, tinia pedis, or tinia capitis.
In deep dermatophytosis the filamentous fungi, dermatophytes, invade the dermis, hypodermis and disseminate to the skin, hair, nails, lymph nodes, and brain.
Associated with immunosuppressive therapy, and the human immunodeficiency virus.
There may be a familial predisposition inherited as an autosomal recessive trait.
Patients have an autosomal recessive CARD9 deficiency (Lanternier F et al ).