Squamous cell carcinoma in situ is histologically described as bowenoid when the keratinocytic atypia predominantly affects the spinous cell layer.
Many lesions of bowenoid SCCIS are derive from preceding human papilloma virus (HPV) infection of numerous different types.
Other causes of bowenoid SCCIS include arsenic exposure and radiation.
Erythroplasia of Queyrat refers to SCCIS on the glans penis.