The aryl hydrocarbon receptor (ArR) is a protein that in humans is encoded by the AHR gene.
The AhR is a transcription factor that regulates gene expression.
Chromosome 7
It regulates metabolism enzymes, and has roles in regulating immunity, stem cell maintenance, and cellular differentiation.
The aryl hydrocarbon receptor is a member of the family of basic helix-loop-helix transcription factors.
AHR binds to several exogenous ligands such as natural plant flavonoids, polyphenolics and indoles, as well as synthetic polycyclic aromatic hydrocarbons and dioxin-like compounds.
AhR is a cytosolic transcription factor that is normally inactive.
The AhR protein is in the family of transcription factors are involved in the binding of the transcription factor to DNA.
Naturally occurring compounds that are ligands of Ahr include derivatives of tryptophan such as indigo dye and indirubin, tetrapyrroles such as bilirubin, the arachidonic acid metabolites lipoxin A4 and prostaglandin G, modified low-density lipoprotein and several dietary carotenoids.
Carbidopa is a selective aryl hydrocarbon receptor modulator (SAhRM).
AhR appears to play a role in the differentiation of many developmental pathways, including hematopoiesis, lymphoid systems, T-cells, neurons, hepatocytes, hematopoietic stem cells
AhR antagonism promotes their self-renewal and ex-vivo expansion and is involved in megakaryocyte differentiation.
The AhR may also signal the presence of toxic chemicals in food and cause aversion of such foods.
AhR activation inhibits inflammation through upregulation of interleukin 22 and downregulation of Th17 response.
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