Anti-cytokine auto antibodies increase susceptibility to severe infections.
These auto antibodies include anti-interferon gamma in mycobacterial diseases, anti-interleukin-6 in staphylococcal disease, anti-interleukin -17 in chronic mucocutaneous candidiasis, antigranulocyte macrophage colony stimulating factor in cryptococcosis or nocardiosis, an anti-type I interferons in COVID– 19, varicella – zoster virus, manifeststations associated with yellow fever vaccine, anti-interleukin – 23 in patients with thymoma, who have antibodies to interleukin – 12.