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Pamidronic acid

Pamidronic acid marketed as Aredia among others, is a nitrogen-containing bisphosphonate used to prevent osteoporosis.

Pregnancy category AU: B3

Routes of administration- Intravenous

Protein binding 54%

Metabolism -Nil

Elimination half-life 28 ± 7 hours

Excretion Renal

Common side effects include bone pain, low calcium levels, nausea, and dizziness.

Pamidronate disodium is a bone resorption inhibitor that absorbs calcium phosphate crystals and prevents the dissolution of this mineral.

It also inhibits osteoclast activity in the bone.

Osteonecrosis of the jaw is a rare complication which has been associated with the use of bisphosphonates, including pamidronate.

Pamidronate activates human γδ T cells in vitro and in vivo, which may lead to flu-like symptoms upon administration.

Relative potency

Bisphosphonate Relative potency Etidronate 1 Tiludronate 10 Pamidronate 100 Alendronate 100-500 Ibandronate 500-1000 Risedronate 1000 Zoledronate 5000

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